There is no scientifically defined dose of cannabis for any specific medical condition. Dosing remains highly individualized and relies to a great extent on titration . However, a mean daily dose of 10–30 mg THC has been used in different studies [4–7]. Chronic use and high dose up to 1,500 mg/day CBD is reportedly well tolerated in humans . Patients are advised to start low and go slow and wait at least 4 hours before taking another oral dose. The daily dosage of oral medical cannabis is generally divided into 3–4 administrations or a single dose prior to bedtime for longer duration of action compared to vaporization . As per recent FDA approval of CBD for the treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients aged 2 years and older, the recommended starting dose is 5 mg/kg/day which can be increased up to a maximum recommended maintenance dose of 20 mg/kg/day .
The general recommended dose for dried cannabis is 1–3 g/day. However, dosing is highly individualized. It is highly recommended to start treatment at a low dose (0.5–1 g/day) and gradually increase the dose to achieve the optimal therapeutic outcome and reduce possible adverse effects.
Patients with no prior experience with cannabis and initiating cannabis therapy for the first time are cautioned to begin at a very low dose and to stop therapy if undesirable side effects occur . For patients with cannabis/cannabinoid usage history, consider current consumption quantity and method of administration (inhalation, oral, or combination).